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Shared Genetic Background Between Cerebrospinal Fluid Biomarkers and Risk for Alzheimer's Disease: A Two-Sample Mendelian Randomization Study.

Journal of Alzheimer's disease : JAD - 1 Jan 2021

Kim Soyeon, Kim Kiwon, Nho Kwangsik, Myung Woojae, Won Hong-Hee

Abstract excerpt

BACKGROUND: Whether the epidemiological association of amyloid-β (Aβ) and tau pathology in late-onset Alzheimer's disease (LOAD) is causal remains unclear. OBJECTIVE: We aimed to investigate the shared genetic background between the cerebrospinal fluid (CSF) biomarkers for Aβ and tau pathology and the risk of LOAD. METHODS: We conducted a two-sample Mendelian randomization (MR) analysis. We used summary...

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Aged, 80 and over
Alzheimer Disease
Amyloid beta-Peptides
Biomarkers
Genome-Wide Association Study

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mendelian Randomization Analysis

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PMID: 33646147
DOI: 10.3233/JAD-200671

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