Article
A gating hinge in Na+ channels; a molecular switch for electrical signaling.
Neuron - 25 Mar 2004
Zhao Yong, Yarov-Yarovoy Vladimir, Scheuer Todd, Catterall William A
Abstract excerpt
Voltage-gated sodium channels are members of a large family with similar pore structures. The mechanism of opening and closing is unknown, but structural studies suggest gating via bending of the inner pore helix at a glycine hinge. Here we provide functional evidence for this gating model for the bacterial sodium channel NaChBac. Mutation of glycine 219 to proline, which would strongly favor bending of the alpha...
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