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Article

Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.

Scientific reports - 9 Jun 2016

Conti Luca, Renhorn Jakob, Gabrielsson Anders, Turesson Fredrik, Liin Sara I, Lindahl Erik, Elinder Fredrik

Abstract excerpt

Voltage-gated potassium channels open at depolarized membrane voltages. A prolonged depolarization causes a rearrangement of the selectivity filter which terminates the conduction of ions - a process called slow or C-type inactivation. How structural rearrangements in the voltage-sensor domain (VSD) cause alteration in the selectivity filter, and vice versa, are not fully understood. We show that pulling the pore...

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Identifiers

PMID: 27278891
DOI: 10.1038/srep27562
PMCID: PMC4899724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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