Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin E-dependent localization of MCM5 regulates centrosome duplication

17 Sept 2008

Abstract excerpt

Centrosomes are the primary microtubule-organizing centers in animal cells and are required for bipolar spindle assembly during mitosis. Amplification of centrosome number is commonly observed in human cancer cells and might contribute to genomic instability. Cyclin E-Cdk2 has been implicated in regulating centrosome duplication both in Xenopus embryos and extracts and in mammalian cells. Localization of cyclin E...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to DNA Repair Mechanisms
Share to Microtubule and mitosis dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18799789
DOI: 10.1242/jcs.034702

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin E-dependent localization of MCM5 regulates centrosome duplicationPMID 18799789Read ↗

CDC25B Involvement in the Centrosome Duplication Cycle and in Microtubule NucleationSemantic proximity Read ↗

Centrosomal localization of cyclins E and A: structural similarities and functional differences.Semantic proximity Read ↗

The MCM Complex: Its Role in DNA Replication and Implications for Cancer TherapySemantic proximity Read ↗

A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry.Semantic proximity Read ↗

Centrosome duplication in mammalian somatic cells requires E2F and Cdk2–Cyclin ASemantic proximity Read ↗

The centrosome cycleSemantic proximity Read ↗

The role of the replication licensing system in cell proliferation and cancer.Semantic proximity Read ↗

MCM7 promotes cancer progression through cyclin D1-dependent signaling and serves as a prognostic marker for patients with hepatocellular carcinomaSemantic proximity Read ↗

Centrosome overduplication, chromosomal instability, and human papillomavirus oncoproteinsSemantic proximity Read ↗

Kinase-independent function of cyclin E.Semantic proximity Read ↗

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.Semantic proximity Read ↗

Cyclin A promotes S-phase entry via interaction with the replication licensing factor Mcm7.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.