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Centrosome overduplication, chromosomal instability, and human papillomavirus oncoproteins

26 Mar 2009

Abstract excerpt

Centrosome aberrations are a frequent finding in human tumors. However, very little is known about the molecular mechanisms leading to disruption of centrosome duplication control and the functional consequences of aberrant centrosome numbers. The high-risk human papillomavirus Type 16 (HPV-16) E6 and E7 oncoproteins are overexpressed in HPV-associated malignancies of the anogenital tract and have been...

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PMID: 19326465
DOI: 10.1002/em.20478

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