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Article

A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry.

Science (New York, N.Y.) - 29 Oct 2004

Matsumoto Yutaka, Maller James L

Abstract excerpt

Excess cyclin E-Cdk2 accelerates entry into S phase of the cell cycle and promotes polyploidy, which may contribute to genomic instability in cancer cells. We identified 20 amino acids in cyclin E as a centrosomal localization signal (CLS) essential for both centrosomal targeting and promoting DN...

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Identifiers

PMID: 15514162
DOI: 10.1126/science.1103544

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-15514162-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry.PMID 15514162Read ↗

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