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Article

Centrosomal localization of cyclins E and A: structural similarities and functional differences.

Cell cycle (Georgetown, Tex.) - 15 Jan 2011

Pascreau Gaetan, Churchill Mair E A, Maller James L

Abstract excerpt

Recent identification of the modular CLS motifs responsible for cyclins A and E localization on centrosomes has revealed a tight linkage between the nuclear and centrosomal cycles. These G1/S cyclins must localize on the centrosome in order for DNA replication to occur in the nucleus, whereas essential DNA replication factors also function on the centrosome to prevent centrosome overduplication. Both events are...

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Identifiers

PMID: 21217199
DOI: 10.4161/cc.10.2.14444
PMCID: PMC3048792

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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