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Article

Cyclin A promotes S-phase entry via interaction with the replication licensing factor Mcm7.

Molecular and cellular biology - 1 Jan 2011

Chibazakura Taku, Kamachi Kazuhiro, Ohara Mayu, Tane Shoji, Yoshikawa Hirofumi, Roberts James M

Abstract excerpt

Cyclin A is known to promote S-phase entry in mammals, but its critical targets in this process have not been defined. We derived a novel human cyclin A mutant (CycA-C1), which can activate cyclin-dependent kinase but cannot promote S-phase entry, and isolated replication licensing factor Mcm7 as a factor that interacts with the wild-type cyclin A but not with the mutant. We demonstrated that human cyclin A and...

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Identifiers

PMID: 21078875
DOI: 10.1128/MCB.00630-10
PMCID: PMC3019979

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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