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Article

Kinase-independent function of cyclin E.

Molecular cell - 12 Jan 2007

Geng Yan, Lee Young-Mi, Welcker Markus, Swanger Jherek, Zagozdzon Agnieszka, Winer Joel D, Roberts James M, Kaldis Philipp, Clurman Bruce E, Sicinski Piotr

Abstract excerpt

E-type cyclins are thought to drive cell-cycle progression by activating cyclin-dependent kinases, primarily CDK2. We previously found that cyclin E-null cells failed to incorporate MCM helicase into DNA prereplication complex during G(0) --> S phase progression. We now report that a kinase-defic...

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Source

Identifiers

PMID: 17218276
DOI: 10.1016/j.molcel.2006.11.029

Genes

CDT1
CDK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17218276-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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