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Article

CDC25B Involvement in the Centrosome Duplication Cycle and in Microtubule Nucleation

15 Dec 2007

Abstract excerpt

Centrosome amplification is frequently reported in human cancers, although the molecular mechanisms that are responsible for this remain unclear. There is significant evidence to support a role for cyclin-dependent kinase (CDK)-cyclin complexes in centrosome duplication. The activities of CDK-cyclin complexes are, in turn, regulated by the CDC25 family of phosphatases in a strict spatiotemporal manner, and we...

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PMID: 18089784
DOI: 10.1158/0008-5472.can-07-2415

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CDC25B Involvement in the Centrosome Duplication Cycle and in Microtubule NucleationPMID 18089784Read ↗

In Vivo Roles of CDC25 Phosphatases: Biological Insight into the Anti-Cancer Therapeutic TargetsSemantic proximity Read ↗

Cyclin E-dependent localization of MCM5 regulates centrosome duplicationSemantic proximity Read ↗

Lats1 suppresses centrosome overduplication by modulating the stability of Cdc25BSemantic proximity Read ↗

Cell Cycle Control by the CDC25 PhosphatasesSemantic proximity Read ↗

Nucleophosmin/B23 is a target of CDK2/cyclin E in centrosome duplication.Semantic proximity Read ↗

CHK1 phosphorylates CDC25B during the cell cycle in the absence of DNA damage.Semantic proximity Read ↗

CDC25B is involved in the centrosomal microtubule nucleation in two-cell stage mouse embryos.Semantic proximity Read ↗

CKAP2 phosphorylation by CDK1/cyclinB1 is crucial for maintaining centrosome integrity.Semantic proximity Read ↗

Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis.Semantic proximity Read ↗

βTrCP-dependent degradation of CDC25B phosphatase at the metaphase-anaphase transition is a pre-requisite for correct mitotic exit.Semantic proximity Read ↗

CDC25B induces cellular senescence and correlates with tumor suppression in a p53-dependent mannerSemantic proximity Read ↗

The DNA replication protein Cdc6 inhibits the microtubule-organizing activity of the centrosome.Semantic proximity Read ↗

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