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Article

DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers.

Oncotarget - 19 Jul 2016

Wang Dunrui, Qian Xiaolan, Rajaram Megha, Durkin Marian E, Lowy Douglas R

Abstract excerpt

The RHO family of RAS-related GTPases in tumors may be activated by reduced levels of RHO GTPase accelerating proteins (GAPs). One common mechanism is decreased expression of one or more members of the Deleted in Liver Cancer (DLC) family of Rho-GAPs, which comprises three closely related genes (DLC1, DLC2, and DLC3) that are down-regulated in a wide range of malignancies. Here we have studied their comparative...

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Share to Cell Movement
Share to DNA Methylation
Share to Down-Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, p53

Share to GTPase-Activating Proteins

Share to Neoplasms

Share to Promoter Regions, Genetic

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 27174913
DOI: 10.18632/oncotarget.9266
PMCID: PMC5216712

Genes

DLC1
RHO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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