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Article

Mechanism of activation of the Formin protein Daam1.

Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2008

Liu Wei, Sato Akira, Khadka Deepak, Bharti Ritu, Diaz Hector, Runnels Loren W, Habas Raymond

Abstract excerpt

The Formin proteins are central players in mediating cytoskeletal reorganization and are epistatically positioned in a pathway downstream of Rho activation. These proteins exist in the cytoplasm in an autoinhibited state, which is mediated by intramolecular interactions between the amino-terminal GTPase binding domain (GBD) that encompasses the diaphanous inhibitory domain (DID) and the carboxyl-terminal...

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Identifiers

PMID: 18162551
DOI: 10.1073/pnas.0707277105
PMCID: PMC2224188

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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