Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A tumor suppressor DLC1: The functions and signal pathways

26 Nov 2019

Abstract excerpt

Deleted in liver cancer-1 (DLC1), a potential tumor suppressor, acts as a GTPase-activating protein for Rho family members. In many human cancers, the DLC1 expression is frequently downregulated or inactivated, which allows cancer cells to proliferate and disseminate. In this review, we describe the characteristics and other members of the DLC1 family and delineate the signal pathways DLC1 involved in regulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to PI3K/AKT/mTOR signaling in cancer
Share to Cancer-related Molecular Pathways
Share to Protein Kinase Regulation and GTPase Signaling

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31773748
DOI: 10.1002/jcp.29402

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A tumor suppressor DLC1: The functions and signal pathwaysPMID 31773748Read ↗

DLC‐1:a Rho GTPase‐activating protein and tumour suppressorSemantic proximity Read ↗

DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers.Semantic proximity Read ↗

Rho GTPase-Activating Protein Deleted in Liver Cancer Suppresses Cell Proliferation and Invasion in Hepatocellular CarcinomaSemantic proximity Read ↗

Deleted in liver cancer protein family in human malignancies (Review)Semantic proximity Read ↗

miR-301b-3p promotes lung adenocarcinoma cell proliferation, migration and invasion by targeting DLC1Semantic proximity Read ↗

Pleiotropic effects of DCLK1 in cancer and cancer stem cellsSemantic proximity Read ↗

Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.Semantic proximity Read ↗

Inhibition of DKC1  Induces Telomere-related Senescence and Apoptosis in Lung Adenocarcinoma Semantic proximity Read ↗

Clinicopathological Significance of DLC-1 Expression in Cancer: a Meta-Analysis.Semantic proximity Read ↗

Expression Patterns and Prognostic Values of ORMDL1 in Different Cancers.Semantic proximity Read ↗

Inhibition of DKC1 induces telomere-related senescence and apoptosis in lung adenocarcinomaSemantic proximity Read ↗

The current status and future of PD-L1 in liver cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.