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Article

Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2007

Qian Xiaolan, Li Guorong, Asmussen Holly K, Asnaghi Laura, Vass William C, Braverman Richard, Yamada Kenneth M, Popescu Nicholas C, Papageorge Alex G, Lowy Douglas R

Abstract excerpt

The three deleted in liver cancer genes (DLC1-3) encode Rho-GTPase-activating proteins (RhoGAPs) whose expression is frequently down-regulated or silenced in a variety of human malignancies. The RhoGAP activity is required for full DLC-dependent tumor suppressor activity. Here we report that DLC1...

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Identifiers

PMID: 17517630
DOI: 10.1073/pnas.0703033104
PMCID: PMC1868654

Genes

DLC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17517630-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Oncogenic inhibition by a deleted in liver cancer gene requires cooperation between tensin binding and Rho-specific GTPase-activating protein activities.PMID 17517630Read ↗

Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function.Semantic proximity Read ↗

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DLC‐1:a Rho GTPase‐activating protein and tumour suppressorSemantic proximity Read ↗

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK).Semantic proximity Read ↗

DLC1 is the principal biologically-relevant down-regulated DLC family member in several cancers.Semantic proximity Read ↗

Deleted in liver cancer protein family in human malignancies (Review)Semantic proximity Read ↗

A tumor suppressor DLC1: The functions and signal pathwaysSemantic proximity Read ↗

Rho GTPase-Activating Protein Deleted in Liver Cancer Suppresses Cell Proliferation and Invasion in Hepatocellular CarcinomaSemantic proximity Read ↗

The molecular and clinical role of Tensin 1/2/3 in cancerSemantic proximity Read ↗

DLC-1, a Rho GTPase-activating protein with tumor suppressor function, is essential for embryonic development.Semantic proximity Read ↗

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration.Semantic proximity Read ↗

Deleted in Liver Cancer (DLC) 2 Encodes a RhoGAP Protein with Growth Suppressor Function and Is Underexpressed in Hepatocellular CarcinomaSemantic proximity Read ↗

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