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Article

The SAM domain of the RhoGAP DLC1 binds EF1A1 to regulate cell migration.

Journal of cell science - 1 Feb 2009

Zhong Dandan, Zhang Jingfeng, Yang Shuai, Soh Unice J K, Buschdorf Jan Paul, Zhou Yi Ting, Yang Daiwen, Low Boon Chuan

Abstract excerpt

Deleted in liver cancer 1 (DLC1) is a multi-modular Rho-GTPase-activating protein (RhoGAP) and a tumor suppressor. Besides its RhoGAP domain, functions of other domains in DLC1 remain largely unknown. By protein precipitation and mass spectrometry, we identified eukaryotic elongation factor 1A1 (EF1A1) as a novel partner for the sterile alpha motif (SAM) domain of DLC1 but not the SAM domain of DLC2. The solution...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 19158340
DOI: 10.1242/jcs.027482

Genes

DLC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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