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Article

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK).

Proceedings of the National Academy of Sciences of the United States of America - 11 Oct 2011

Li Guorong, Du Xiaoli, Vass William C, Papageorge Alex G, Lowy Douglas R, Qian Xiaolan

Abstract excerpt

The deleted in liver cancer 1 (DLC1) tumor suppressor gene, which is frequently inactivated in cancer, encodes a Rho-GAP (GTPase activating protein) focal adhesion protein whose negative regulation of Rho-GTPases is necessary but not sufficient for its full tumor suppressor activity. Here, we report that DLC1 forms a complex with two prooncogenic focal adhesion proteins, talin and the focal adhesion kinase (FAK)....

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Identifiers

PMID: 21969587
DOI: 10.1073/pnas.1112122108
PMCID: PMC3193248

Genes

DLC1

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