Article

DLC1 loss drives multicellular streaming invasion by enforcing spatially coordinated Rho and β1 integrin signaling

2026-06-23

Abstract excerpt

Efficient cancer cell invasion requires coordinated control of actomyosin contractility, extracellular matrix (ECM) engagement and remodeling, yet how these processes are integrated in complex, three-dimensional (3D) environments remains unclear. Here, we identify the tumor suppressor and RhoGAP protein DLC1 as molecular brake on multicellular streaming invasion in collagen-rich ECM. Using CRISPRoff-engineered bre...

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Literature Corpus work: abc615d8-41f1-5464-a171-365ff7c4b477
DOI: 10.64898/2026.06.22.733747

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