Article
Potentials of Shigella flexneri Y strain TSF21 as a candidate vaccine against shigellosis: safety, immunogenicity and protective efficacy in Bonnet monkeys.
FEMS microbiology immunology - 1 Jun 1991
Ashraf M M, Giri D K, Batra H V, Khandekar P, Ahmed Z U, Talwar G P
Abstract excerpt
A thymine-requiring and temperature-sensitive mutant of Shigella flexneri Y was tested in Bonnet monkeys for safety, immunogenicity and protective efficacy. A dose of 10(11) cells when fed orally mimicked natural infection in having invaded epithelial cells, but was otherwise clinically non-reactogenic. Animals immunized with two oral doses, each dose consisting of 1 x 10(11) mutant bacteria, were fully protected...
Topics
- Administration, Oral
- Animals
- Antibodies, Bacterial
- Bacterial Vaccines
- Digestive System
- Dysentery, Bacillary
- Enzyme-Linked Immunosorbent Assay
- Immunization
- Macaca radiata
- Macrophages