Article
Isolation and characterization of temperature-sensitive mutants of Streptococcus suis: efficacy trial of the mutant vaccine in mice.
Veterinary microbiology - 1 Apr 1990
Kebede M, Chengappa M M, Stuart J G
Abstract excerpt
A model of experimental Streptococcus suis infection was developed in young mice. Minimum lethal dose (MLD) values were calculated for four virulent serotypes (1/2, 1, 2, 3) of S. suis using this model. Temperature-sensitive (ts) mutants of S. suis serotypes 1/2 and 1-8 were isolated and characterized on the basis of their growth kinetics and reversion rates. Ts mutants of S. suis 1/2, 1, 2, and 3 were tested as...
Topics
- Animals
- Bacterial Vaccines
- Colony Count, Microbial
- Disease Models, Animal
- Kinetics
- Mice
- Mutation
- Streptococcal Infections
- Streptococcus
- Swine
- Swine Diseases