Live attenuated Shigella flexneri mutants as vaccine candidates against shigellosis and vectors for antigen delivery.

doi:10.1006/biol.1995.0023

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Article

Live attenuated Shigella flexneri mutants as vaccine candidates against shigellosis and vectors for antigen delivery.

Biologicals : journal of the International Association of Biological Standardization - 1 Jun 1995

Phalipon A, Sansonetti P

Abstract excerpt

Up to now, no effective vaccine is available against shigellosis, a dysenteric syndrome caused by Shigella, a Gram-negative bacterium which invades the human colonic mucosa. About 40 years of research in the field have led to the conclusion that orally administered live Shigella vaccine strains a...

Topics

Animals
Antigens, Bacterial
Bacterial Vaccines
Carbohydrate Sequence
Dysentery, Bacillary
Humans
Molecular Sequence Data
Mutation
Shigella flexneri
Virulence

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