Article
Virulent non-capsulate Yersinia pestis variants constructed by insertion mutagenesis.
Journal of medical microbiology - 1 Apr 1995
Drozdov I G, Anisimov A P, Samoilova S V, Yezhov I N, Yeremin S A, Karlyshev A V, Krasilnikova V M, Kravchenko V I
Abstract excerpt
Insertion mutagenesis with the help of the plasmid pFS23 was used to generate Yersinia pestis fra mutants. The results of pFra- strain production under non-selective conditions suggested that such Y. pestis variants may be generated in natural plague foci at high frequency and may participate in supporting the epizootic process. Present data suggest that the reduction of virulence in Fra- strains reported by the...
Topics
- Animals
- Antigens, Bacterial
- Bacterial Toxins
- Genes, Bacterial
- Guinea Pigs
- Lethal Dose 50
- Mice
- Mutagenesis, Insertional
- Operon
- Phenotype
- Plague