Live oral auxotrophic Shigella flexneri SFL124 vaccine with a deleted aroD gene: characterization and monkey protection studies.

doi:10.1016/0264-410x(92)90069-v

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Article

Live oral auxotrophic Shigella flexneri SFL124 vaccine with a deleted aroD gene: characterization and monkey protection studies.

Vaccine - 1 Jan 1992

Kärnell A, Stocker B A, Katakura S, Reinholt F P, Lindberg A A

Abstract excerpt

Shigella flexneri SFL124, with a deletion encompassing all, or nearly all, of the coding sequence of gene aroD was obtained after selection on a fusaric acid medium supplemented with 2,3-dihydroxybenzoic acid for tetracycline-sensitive mutants of S. flexneri SFL114 which is an aroD::Tn10 transductant. Two of 20 tetracycline-sensitive mutants tested in colony hybridization with a 32P-labelled DNA probe of...

Topics

Administration, Oral
Animals
Antibodies
Bacterial Vaccines
Chromosome Deletion
Congo Red
Dysentery, Bacillary
Female
Guinea Pigs
HeLa Cells
Humans
Immunoenzyme Techniques

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Immunoglobulin A

Immunoglobulin G

Intestine, Large

Macaca fascicularis

Mutation

Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 1598787
DOI: 10.1016/0264-410x(92)90069-v

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1598787-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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