Article
Construction and evaluation of a virG thyA double mutant of Shigella flexneri 2a as a candidate live-attenuated oral vaccine.
Vaccine - 1 Jan 1995
Yoshikawa M, Sasakawa C, Okada N, Takasaka M, Nakayama M, Yoshikawa Y, Kohno A, Danbara H, Nariuchi H, Shimada H
Abstract excerpt
A virG thyA double mutant of Shigella flexneri 2a was constructed as a candidate live-attenuated oral vaccine. In the keratoconjunctivitis model it did not provoke any adverse reaction by itself on guinea pigs' eyes and completely protected them from provoking keratoconjunctivitis. When (2.7-4.8) x 10(10) of the vaccine was inoculated intragastrically after 1 day fasting in cynomolgus monkeys three times at...
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