Article
Persistent hepatitis C virus infection in a chimpanzee is associated with emergence of a cytotoxic T lymphocyte escape variant.
Proceedings of the National Academy of Sciences of the United States of America - 28 Mar 1995
Weiner A, Erickson A L, Kansopon J, Crawford K, Muchmore E, Hughes A L, Houghton M, Walker C M
Abstract excerpt
Hepatitis C virus (HCV) establishes a persistent infection in humans and chimpanzees despite the presence of virus-specific, class I major histocompatibility complex-restricted CD8+ cytotoxic T lymphocytes (CTLs) in the liver. The data presented here demonstrate that CTLs directed against a conserved epitope in the HCV nonstructural 3 protein persist in the liver of a chronically infected chimpanzee for at least...
Topics
- Amino Acid Sequence
- Animals
- Aspartic Acid
- Base Sequence
- CD8-Positive T-Lymphocytes
- Cell Line
- Conserved Sequence
- Cytotoxicity, Immunologic
- DNA Primers
- Genetic Variation