Article
Association of cytotoxic T lymphocyte (CTL) escape mutations with persistent hepatitis C virus (HCV) infection.
Princess Takamatsu symposia - 1 Jan 1995
Weiner A J, Erickson A L, Kansopon J, Crawford K, Muchmore E, Houghton M, Walker C M
Abstract excerpt
Mechanisms by which HCV evades the cellular immune response in persistently infected humans and chimpanzees are poorly defined, but could involve mutations in epitopes recognized by class I MHC restricted CTLs. To investigate this possibility, we identified an epitope in the NS3 protein of HCV th...
Topics
- Amino Acid Sequence
- Epitopes
- Hepatitis C
- Histocompatibility Antigens Class I
- Humans
- Molecular Sequence Data
- Mutation
- T-Lymphocytes, Cytotoxic