Article
Multiple kinesin motors coordinate cytoplasmic RNA transport on a subpopulation of microtubules in Xenopus oocytes.
Developmental cell - 1 Sept 2008
Messitt Timothy J, Gagnon James A, Kreiling Jill A, Pratt Catherine A, Yoon Young J, Mowry Kimberly L
Abstract excerpt
RNA localization is a widely conserved mechanism for generating cellular asymmetry. In Xenopus oocytes, microtubule-dependent transport of RNAs to the vegetal cortex underlies germ layer patterning. Although kinesin motors have been implicated in this process, the apparent polarity of the microtubule cytoskeleton has pointed instead to roles for minus-end-directed motors. To resolve this issue, we have analyzed...
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