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Article

Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior.

Nature cell biology - 1 Aug 2002

Cha Byeong-Jik, Serbus Laura R, Koppetsch Birgit S, Theurkauf William E

Abstract excerpt

Microtubules and the plus-end-directed microtubule motor Kinesin I are required for the selective accumulation of oskar mRNA at the posterior cortex of the Drosophila melanogaster oocyte, which is essential to posterior patterning and pole plasm assembly. We present evidence that microtubule minus ends associate with the entire cortex, and that Kinesin and microtubules are not required for oskar mRNA association...

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Identifiers

PMID: 12134163
DOI: 10.1038/ncb832

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Kinesin I-dependent cortical exclusion restricts pole plasm to the oocyte posterior.PMID 12134163Read ↗

Oskar organizes the germ plasm and directs localization of the posterior determinant nanos.Semantic proximity Read ↗

Transient posterior localization of a kinesin fusion protein reflects anteroposterior polarity of the Drosophila oocyte.Semantic proximity Read ↗

Follicle cell contact maintains main body axis polarity in the <i>Drosophila melanogaster</i> oocyteSemantic proximity Read ↗

The endocytic pathway acts downstream of Oskar in Drosophila germ plasm assembly.Semantic proximity Read ↗

Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior pole.Semantic proximity Read ↗

Multiple kinesin motors coordinate cytoplasmic RNA transport on a subpopulation of microtubules in Xenopus oocytes.Semantic proximity Read ↗

Drosophila Y14 shuttles to the posterior of the oocyte and is required for oskar mRNA transport.Semantic proximity Read ↗

Requirement for Drosophila cytoplasmic tropomyosin in oskar mRNA localization.Semantic proximity Read ↗

oskar mRNA is localized to the posterior pole of the Drosophila oocyte.Semantic proximity Read ↗

A late phase of germ plasm accumulation during Drosophila oogenesis requires lost and rumpelstiltskin.Semantic proximity Read ↗

The actin-binding protein Lasp promotes Oskar accumulation at the posterior pole of the Drosophila embryo.Semantic proximity Read ↗

Kinesin-1 and cytoplasmic dynein act sequentially to move the meiotic spindle to the oocyte cortex in Caenorhabditis elegans.Semantic proximity Read ↗

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