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Article

Growing microtubules push the oocyte nucleus to polarize the Drosophila dorsal-ventral axis.

Science (New York, N.Y.) - 25 May 2012

Zhao Tongtong, Graham Owen S, Raposo Alexandre, St Johnston Daniel

Abstract excerpt

The Drosophila dorsal-ventral (DV) axis is polarized when the oocyte nucleus migrates from the posterior to the anterior margin of the oocyte. Prior work suggested that dynein pulls the nucleus to the anterior side along a polarized microtubule cytoskeleton, but this mechanism has not been tested. By imaging live oocytes, we find that the nucleus migrates with a posterior indentation that correlates with its...

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Identifiers

PMID: 22499806
DOI: 10.1126/science.1219147
PMCID: PMC3459055

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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