Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Actin protects mammalian eggs against chromosome segregation errors

25 Aug 2017

Abstract excerpt

Chromosome segregation is driven by a spindle that is made of microtubules but is generally thought to be independent of actin. Here, we report an unexpected actin-dependent mechanism that drives the accurate alignment and segregation of chromosomes in mammalian eggs. Prominent actin filaments permeated the microtubule spindle in eggs of several mammalian species, including humans. Disrupting actin in mouse eggs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomal and Genetic Variations
Share to Microtubule and mitosis dynamics
Share to Reproductive Biology and Fertility

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 28839045
DOI: 10.1126/science.aal1647

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Actin protects mammalian eggs against chromosome segregation errorsPMID 28839045Read ↗

Actin organizes chromosomes and microtubules to ensure mitotic fidelity in the preimplantation embryoSemantic proximity Read ↗

Recent Insights into Spindle Function in Mammalian Oocytes and Early Embryos1Semantic proximity Read ↗

Actin-driven chromosome clustering facilitates fast and complete chromosome capture in mammalian oocytesSemantic proximity Read ↗

Meiotic spindle formation in mammalian oocytes: implications for human infertility†Semantic proximity Read ↗

Actin limits egg aneuploidies associated with female reproductive agingSemantic proximity Read ↗

Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproductionSemantic proximity Read ↗

Assembly and Positioning of the Oocyte Meiotic SpindleSemantic proximity Read ↗

Live imaging RNAi screen reveals genes essential for meiosis in mammalian oocytes.Semantic proximity Read ↗

Regulation of chromosome segregation in oocytes and the cellular basis for female meiotic errorsSemantic proximity Read ↗

Actin-based spindle positioning: new insights from female gametesSemantic proximity Read ↗

Initial spindle positioning at the oocyte center protects against incorrect kinetochore-microtubule attachment and aneuploidy in miceSemantic proximity Read ↗

Error-prone chromosome-mediated spindle assembly favors chromosome segregation defects in human oocytesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.