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Article

Polar relaxation by dynein-mediated removal of cortical myosin II.

The Journal of cell biology - 3 Aug 2020

Chapa-Y-Lazo Bernardo, Hamanaka Motonari, Wray Alexander, Balasubramanian Mohan K, Mishima Masanori

Abstract excerpt

Nearly six decades ago, Lewis Wolpert proposed the relaxation of the polar cell cortex by the radial arrays of astral microtubules as a mechanism for cleavage furrow induction. While this mechanism has remained controversial, recent work has provided evidence for polar relaxation by astral microtubules, although its molecular mechanisms remain elusive. Here, using C. elegans embryos, we show that polar relaxation...

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Identifiers

PMID: 32497213
DOI: 10.1083/jcb.201903080
PMCID: PMC7401816

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