Article
Kinesin-3 and dynein mediate microtubule-dependent co-transport of mRNPs and endosomes.
Journal of cell science - 1 Jun 2012
Baumann Sebastian, Pohlmann Thomas, Jungbluth Marc, Brachmann Andreas, Feldbrügge Michael
Abstract excerpt
Long-distance transport of mRNAs is important in determining polarity in eukaryotes. Molecular motors shuttle large ribonucleoprotein complexes (mRNPs) containing RNA-binding proteins and associated factors along microtubules. However, precise mechanisms including the interplay of molecular motors and a potential connection to membrane trafficking remain elusive. Here, we solve the motor composition of...
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