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Article

Essential involvement of CX3CR1-mediated signals in the bactericidal host defense during septic peritonitis.

Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2008

Ishida Yuko, Hayashi Takahito, Goto Takatsugu, Kimura Akihiko, Akimoto Shigeru, Mukaida Naofumi, Kondo Toshikazu

Abstract excerpt

Cecal ligation and puncture (CLP) caused septic peritonitis in wild-type (WT) mice, with approximately 33% mortality within 7 days after the procedure. Concomitantly, the protein level of intraperitoneal CX3CL1/fractalkine was increased, with infiltration by CX3CR1-expressing macrophages into the peritoneum. CLP induced 75% mortality in CX3CR1-deficient (CX3CR1(-/-)) mice, which, however, exhibited a similar...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 18768878
DOI: 10.4049/jimmunol.181.6.4208

Genes

TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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