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Article

CCR1 and CC chemokine ligand 5 interactions exacerbate innate immune responses during sepsis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2004

Ness Traci L, Carpenter Kristin J, Ewing Jillian L, Gerard Craig J, Hogaboam Cory M, Kunkel Steven L

Abstract excerpt

CCR1 has previously been shown to play important roles in leukocyte trafficking, pathogen clearance, and the type 1/type 2 cytokine balance, although very little is known about its role in the host response during sepsis. In a cecal ligation and puncture model of septic peritonitis, CCR1-deficient (CCR1(-/-)) mice were significantly protected from the lethal effects of sepsis when compared with wild-type (WT)...

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Topics

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Chemokine CCL5

Share to Chemotaxis, Leukocyte

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Share to Macrophages, Peritoneal

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Source

Identifiers

PMID: 15557190
DOI: 10.4049/jimmunol.173.11.6938

Genes

CCR1
CCL5
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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