Article
Increased susceptibility to septic and endotoxic shock in monocyte chemoattractant protein 1/cc chemokine ligand 2-deficient mice correlates with reduced interleukin 10 and enhanced macrophage migration inhibitory factor production.
Shock (Augusta, Ga.) - 1 Nov 2006
Gomes Rachel N, Figueiredo Rodrigo T, Bozza Fernando A, Pacheco Patrícia, Amâncio Rodrigo T, Laranjeira Andréa P, Castro-Faria-Neto Hugo C, Bozza Patrícia T, Bozza Marcelo T
Abstract excerpt
The chemokine monocyte chemoattractant protein 1/CC chemokine ligand 2 (MCP-1/CCL2) is a potent chemoattractant of mononuclear cells and a regulatory mediator involved in a variety of inflammatory diseases. In the present study, we demonstrate that mcp-1/ccl2-deficient mice are more susceptible to systemic inflammatory response syndrome induced by lipopolysaccharide and to polymicrobial sepsis induced by cecum...
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