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Article

Inhibition of mPGES-1 attenuates efficient resolution of acute inflammation by enhancing CX3CL1 expression.

Cell death & disease - 2 Feb 2021

Rappl Peter, Rösser Silvia, Maul Patrick, Bauer Rebekka, Huard Arnaud, Schreiber Yannick, Thomas Dominique, Geisslinger Gerd, Jakobsson Per-Johan, Weigert Andreas, Brüne Bernhard, Schmid Tobias

Abstract excerpt

Despite the progress to understand inflammatory reactions, mechanisms causing their resolution remain poorly understood. Prostanoids, especially prostaglandin E2 (PGE2), are well-characterized mediators of inflammation. PGE2 is produced in an inducible manner in macrophages (Mϕ) by microsomal PGE2-synthase-1 (mPGES-1), with the notion that it also conveys pro-resolving properties. We aimed to characterize the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33542207
DOI: 10.1038/s41419-021-03423-2
PMCID: PMC7862376

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