Article
TLR4 influences the humoral and cellular immune response during polymicrobial sepsis.
Injury - 1 Oct 2010
Gosemann Jan H, van Griensven Martijn, Barkhausen Tanja, Kobbe Philipp, Thobe Björn M, Haasper Carl, Pape Hans C, Krettek Christian, Hildebrand Frank, Frink Michael
Abstract excerpt
As part of the innate immune system, Toll-like receptors (TLRs) react rapidly on a pathogen challenge without prior exposure. Although it is well known that TLR4 is associated with the receptor for lipopolysaccharide (LPS), its role during sepsis has not yet been clearly defined. To study this,polymicrobial sepsis was induced in male C3H/HeN (TLR4 wild type) and C3H/HeJ (TLR4 mutant) mice by caecal ligation and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.