Article
CCR2-deficient mice are protected to sepsis by the disruption of the inflammatory monocytes emigration from the bone marrow.
Journal of leukocyte biology - 1 Jun 2021
Cebinelli Guilherme Cesar Martelossi, de Lima Kalil Alves, Silva Castanheira Fernanda Vargas E, Hiroki Carlos Hiroji, Monteiro Valter Vinícius Silva, de Lima Mikhael Haruo Fernandes, Nascimento Daniele Carvalho Bernardo, Alves Filho José Carlos, Cunha Thiago Mattar, Cunha Fernando de Queiroz
Abstract excerpt
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated host response to infection. Inflammatory monocytes are recruited to both the infection site and vital organs during sepsis; however, the mechanisms that orchestrate their migration, as well as the participation of these cells in systemic inflammation and vital organ damage, are still not fully elucidated. In this context, we...
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