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Article

Dual activation of phospholipase C-epsilon by Rho and Ras GTPases.

The Journal of biological chemistry - 31 Oct 2008

Seifert Jason P, Zhou Yixing, Hicks Stephanie N, Sondek John, Harden T Kendall

Abstract excerpt

Phospholipase C-epsilon (PLC-epsilon) is a highly elaborated PLC required for a diverse set of signaling pathways. Here we use a combination of cellular assays and studies with purified proteins to show that activated RhoA and Ras isoforms directly engage distinct regions of PLC-epsilon to stimulate its phospholipase activity. Purified PLC-epsilon was activated in a guanine nucleotide- and concentration-dependent...

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Identifiers

PMID: 18765661
DOI: 10.1074/jbc.M805038200
PMCID: PMC2573092

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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