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Article

Isozyme-specific stimulation of phospholipase C-gamma2 by Rac GTPases.

The Journal of biological chemistry - 25 Nov 2005

Piechulek Thomas, Rehlen Tobias, Walliser Claudia, Vatter Petra, Moepps Barbara, Gierschik Peter

Abstract excerpt

The regulation of the two isoforms of phospholipase C-gamma, PLCgamma(1) and PLCgamma(2), by cell surface receptors involves protein tyrosine phosphorylation as well as interaction with adapter proteins and phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)) generated by inositol phospholipid 3-kinases (PI3Ks). All three processes may lead to recruitment of the PLCgamma isozymes to the plasma membrane and/or...

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Identifiers

PMID: 16172125
DOI: 10.1074/jbc.M509396200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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