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Article

Crystal structure of Rac1 bound to its effector phospholipase C-beta2.

Nature structural & molecular biology - 1 Dec 2006

Jezyk Mark R, Snyder Jason T, Gershberg Svetlana, Worthylake David K, Harden T Kendall, Sondek John

Abstract excerpt

Although diverse signaling cascades require the coordinated regulation of heterotrimeric G proteins and small GTPases, these connections remain poorly understood. We present the crystal structure of the GTPase Rac1 bound to phospholipase C-beta2 (PLC-beta2), a classic effector of heterotrimeric G proteins. Rac1 engages the pleckstrin-homology (PH) domain of PLC-beta2 to optimize its orientation for substrate...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17115053
DOI: 10.1038/nsmb1175

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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