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Article

Intramolecular regulation of phospholipase C-gamma1 by its C-terminal Src homology 2 domain.

Molecular and cellular biology - 1 Feb 2007

DeBell Karen, Graham Laurie, Reischl Ilona, Serrano Carmen, Bonvini Ezio, Rellahan Barbara

Abstract excerpt

Phosphoinositide-specific phospholipase C-gamma1 (PLC-gamma1) is a key enzyme that governs cellular functions such as gene transcription, secretion, proliferation, motility, and development. Here, we show that PLC-gamma1 is regulated via a novel autoinhibitory mechanism involving its carboxy-terminal Src homology (SH2C) domain. Mutation of the SH2C domain tyrosine binding site led to constitutive PLC-gamma1...

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Identifiers

PMID: 17116690
DOI: 10.1128/MCB.01400-06
PMCID: PMC1800685

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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