Article
Phospholipase Cepsilon is a nexus for Rho and Rap-mediated G protein-coupled receptor-induced astrocyte proliferation.
Proceedings of the National Academy of Sciences of the United States of America - 25 Sept 2007
Citro Simona, Malik Sundeep, Oestreich Emily A, Radeff-Huang Julie, Kelley Grant G, Smrcka Alan V, Brown Joan Heller
Abstract excerpt
Phospholipase Cepsilon (PLCepsilon) has been suggested to transduce signals from small GTPases, but its biological function has not yet been clarified. Using astrocytes from PLCepsilon-deficient mice, we demonstrate that endogenous G protein-coupled receptors (GPCRs) for lysophosphatidic acid, sphingosine 1-phosphate, and thrombin regulate phosphoinositide hydrolysis primarily through PLCepsilon. Stimulation by...
Topics
- Animals
- Astrocytes
- Carbachol
- Cell Proliferation
- GTP Phosphohydrolases
- Genotype
- Lysophospholipids
- Mice
- Mice, Knockout
- Mice, Transgenic