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Article

Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection.

The Journal of clinical investigation - 1 Feb 2002

Ping Peipei, Song Changxu, Zhang Jun, Guo Yiru, Cao Xinan, Li Richard C X, Wu Wenjian, Vondriska Thomas M, Pass Jason M, Tang Xian-Liang, Pierce William M, Bolli Roberto

Abstract excerpt

The epsilon isoform of protein kinase C (PKCepsilon) is a member of the PKC family of serine/threonine kinases and plays a critical role in protection against ischemic injury in multiple organs. Functional proteomic analyses of PKCepsilon signaling show that this isozyme forms multiprotein complexes in the heart; however, the precise signaling mechanisms whereby PKCepsilon orchestrates cardioprotection are poorly...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11854322
DOI: 10.1172/JCI13200
PMCID: PMC150872

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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