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Article

Activation of JNK by Epac is independent of its activity as a Rap guanine nucleotide exchanger.

The Journal of biological chemistry - 5 Sept 2003

Hochbaum Daniel, Tanos Tamara, Ribeiro-Neto Fernando, Altschuler Daniel, Coso Omar A

Abstract excerpt

Guanine nucleotide exchange factors (GEFs) and their associated GTP-binding proteins (G-proteins) are key regulatory elements in the signal transduction machinery that relays information from the extracellular environment into specific intracellular responses. Among them, the MAPK cascades represent ubiquitous downstream effector pathways. We have previously described that, analogous to the Ras-dependent...

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Identifiers

PMID: 12783872
DOI: 10.1074/jbc.M305208200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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