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Article

Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase.

Molecular and cellular biology - 1 Feb 1997

Cai H, Smola U, Wixler V, Eisenmann-Tappe I, Diaz-Meco M T, Moscat J, Rapp U, Cooper G M

Abstract excerpt

The Raf protein kinases function downstream of Ras guanine nucleotide-binding proteins to transduce intracellular signals from growth factor receptors. Interaction with Ras recruits Raf to the plasma membrane, but the subsequent mechanism of Raf activation has not been established. Previous studies implicated hydrolysis of phosphatidylcholine (PC) in Raf activation; therefore, we investigated the role of the...

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Identifiers

PMID: 9001227
DOI: 10.1128/MCB.17.2.732
PMCID: PMC231799

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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