Article
Role of diacylglycerol-regulated protein kinase C isotypes in growth factor activation of the Raf-1 protein kinase.
Molecular and cellular biology - 1 Feb 1997
Cai H, Smola U, Wixler V, Eisenmann-Tappe I, Diaz-Meco M T, Moscat J, Rapp U, Cooper G M
Abstract excerpt
The Raf protein kinases function downstream of Ras guanine nucleotide-binding proteins to transduce intracellular signals from growth factor receptors. Interaction with Ras recruits Raf to the plasma membrane, but the subsequent mechanism of Raf activation has not been established. Previous studi...
Topics
- 3T3 Cells
- Animals
- COS Cells
- Cell Division
- Cell Line
- Diglycerides
- Enzyme Activation
- Epidermal Growth Factor
- Isoenzymes
- Mice
- Mitogens
- Mutation
- Protein Kinase C
- Protein Kinase C-alpha
- Protein Kinase C-epsilon
- Protein Serine-Threonine Kinases