Article
Characterization of phospholipase C gamma enzymes with gain-of-function mutations.
The Journal of biological chemistry - 21 Aug 2009
Everett Katy L, Bunney Tom D, Yoon Youngdae, Rodrigues-Lima Fernando, Harris Richard, Driscoll Paul C, Abe Koichiro, Fuchs Helmut, de Angelis Martin Hrabé, Yu Philipp, Cho Wohnwa, Katan Matilda
Abstract excerpt
Phospholipase C gamma isozymes (PLC gamma 1 and PLC gamma 2) have a crucial role in the regulation of a variety of cellular functions. Both enzymes have also been implicated in signaling events underlying aberrant cellular responses. Using N-ethyl-N-nitrosourea (ENU) mutagenesis, we have recently identified single point mutations in murine PLC gamma 2 that lead to spontaneous inflammation and autoimmunity. Here...
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