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Article

Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B.

The Journal of biological chemistry - 10 May 2002

Evellin Sandrine, Nolte Jan, Tysack Karina, vom Dorp Frank, Thiel Markus, Weernink Paschal A Oude, Jakobs Karl H, Webb Edwin J, Lomasney Jon W, Schmidt Martina

Abstract excerpt

Stimulation of phospholipase C (PLC) by G(q)-coupled receptors such as the M(3) muscarinic acetylcholine receptor (mAChR) is caused by direct activation of PLC-beta enzymes by Galpha(q) proteins. We have recently shown that G(s)-coupled receptors can stimulate PLC-epsilon, apparently via formation of cyclic AMP and activation of the Ras-related GTPase Rap2B. Here we report that PLC stimulation by the M(3) mAChR...

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Identifiers

PMID: 11877431
DOI: 10.1074/jbc.M112024200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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