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Article

Long-term proteasome dysfunction in the mouse brain by expression of aberrant ubiquitin.

Neurobiology of aging - 1 Jun 2009

Fischer David F, van Dijk Renske, van Tijn Paula, Hobo Barbara, Verhage Marian C, van der Schors Roel C, Li Ka Wan, van Minnen Jan, Hol Elly M, van Leeuwen Fred W

Abstract excerpt

Many neurodegenerative diseases are characterized by deposits of ubiquitinated and aberrant proteins, suggesting a failure of the ubiquitin-proteasome system (UPS). The aberrant ubiquitin UBB(+1) is one of the ubiquitinated proteins accumulating in tauopathies such as Alzheimer's disease (AD) and polyglutamine diseases such as Huntington's disease. We have generated UBB(+1) transgenic mouse lines with post-natal...

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Identifiers

PMID: 18760506
DOI: 10.1016/j.neurobiolaging.2008.06.009

Genes

UBB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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