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Article

Delayed spinocerebellar ataxia in transgenic mice expressing mutant ubiquitin.

Neuropathology and applied neurobiology - 1 Feb 2006

Tsirigotis M, Tang M Y, Beyers M, Zhang M, Woulfe J, Gray D A

Abstract excerpt

Spinocerebellar ataxia type 1 (SCA1) is an incurable neurodegenerative disease resulting from loss of Purkinje neurones within the cerebellum. The ubiquitin proteasome pathway (UPP) has been implicated in SCA1 but the role of proteolysis in the disease is still poorly understood. To further investigate this issue in vivo, genetic crosses were performed between an established mouse model of SCA1 and novel strains...

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Identifiers

PMID: 16409551
DOI: 10.1111/j.1365-2990.2005.00694.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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