Article
Long-term proteasomal inhibition in transgenic mice by UBB(+1) expression results in dysfunction of central respiration control reminiscent of brainstem neuropathology in Alzheimer patients.
Acta neuropathologica - 1 Aug 2012
Irmler Martin, Gentier Romina J G, Dennissen Frank J A, Schulz Holger, Bolle Ines, Hölter Sabine M, Kallnik Magdalena, Cheng Jing Jun, Klingenspor Martin, Rozman Jan, Ehrhardt Nicole, Hermes Denise J H P, Gailus-Durner Valérie, Fuchs Helmut, Hrabě de Angelis Martin, Meyer Helmut E, Hopkins David A, Van Leeuwen Fred W, Beckers Johannes
Abstract excerpt
Aging and neurodegeneration are often accompanied by a functionally impaired ubiquitin-proteasome system (UPS). In tauopathies and polyglutamine diseases, a mutant form of ubiquitin B (UBB(+1)) accumulates in disease-specific aggregates. UBB(+1) mRNA is generated at low levels in vivo during tran...
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